Cytochrome P450 3A1 / CYP3A1 (P6), CF405S conjugate, 0.1mg/mL

About this product

Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P450s are membrane-bound, either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells where they metabolise thousands of endogenous and exogenous compounds. In the liver, these substrates include toxins, drugs, and other unneeded and potentially harmful molecules. Humans have 18 families of cytochrome P450 genes and 43 subfamilies; the CYP1 family is involved in drug metabolism and includes 3 subfamilies, 3 genes and 1 pseudogene. The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. P6 is highly specific for members of the CYP 3A gene family and cross reacts with CY 3A4 in human, CYP 3A in rat and potentially CYP 3A11 (based on inducibility) in mice. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC043058-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

CYP3A1; Cytochrome P450 family 3 subfamily A polypeptide 1

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

CYP3A1

Gene ID

Not Known

NCBI Gene ID

Not Known

UniProt

Not Known

Swiss Prot

Not Known

Host

Mouse

Species Reactivity

Human, Mouse, Pig, Rat

Reactivity

CYP3A1|Cytochrome P450 3A1

Immunogen

Full length protein (Rat) . Rat liver cytochrome P450 3A1.

Target Antigen

CYP3A1 | Cytochrome P450 3A1

Clonality

Monoclonal

Clone

P6

Type

Primary

Source

Animal

Origin

Animal

Applications

ELISA (published) |WB (published)

Positive Control

HeLa cells. Liver or Cardiac muscle.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

51 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Eur J Biochem (1993) 213: 805-814. (cell ELISA) Toxicol in Vitro (1994) 8(3): 423-35. (ELISA) Drug Metab Disp (2001) 29(3) Pt 2: 353-360. (WB)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF405S