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Product details
Catalog number BNC473058-500
Price for BNC473058-500
Size / count 1x 500 µL
Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P450s are membrane-bound, either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells where they metabolise thousands of endogenous and exogenous compounds. In the liver, these substrates include toxins, drugs, and other unneeded and potentially harmful molecules. Humans have 18 families of cytochrome P450 genes and 43 subfamilies; the CYP1 family is involved in drug metabolism and includes 3 subfamilies, 3 genes and 1 pseudogene. The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. P6 is highly specific for members of the CYP 3A gene family and cross reacts with CY 3A4 in human, CYP 3A in rat and potentially CYP 3A11 (based on inducibility) in mice. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Cytochrome P450 3A1 / CYP3A1 (P6), CF647 conjugate, 0.1mg/mL is BNC473058-500.
Cytochrome P450 3A1 / CYP3A1 (P6), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.
Cytochrome P450 3A1 / CYP3A1 (P6), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Cytochrome P450 3A1 / CYP3A1 (P6), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for Cytochrome P450 3A1 / CYP3A1 (P6), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Cytochrome P450 3A1 / CYP3A1 (P6), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a6061270361e105f39/msds/bnc473058-500.pdf.
Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P45
Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.
If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.
The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.
