CLEC9A / DNGR1 (Dendritic Cell Marker) (8F9), 1mg/mL

About this product

This MAb recognizes a protein of 27 kDa, identified as CLEC9A (C-type lectin domain family 9 member A) . Its epitopes maps in aa 50-110. The C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLEC-9A, also known as DNGR1 (dendritic cell natural killer lectin group receptor 1), is a 241 amino acid single-pass type II membrane protein that contains one C-type lectin domain and belongs to the CTL/CTLD superfamily. Expressed in myeloid lineage cells, brain, spleen and thymus, CLEC-9A is a group V C-type lectin- like receptor (CTLR) that acts as an activation receptor. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUM3063-50

Size / count

1x 50 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

C-type lectin domain family 9 member A (CLEC9A) ; DNGR1

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

CLEC9A

Gene ID

283420

NCBI Gene ID

531189

UniProt

Q6UXN8

Swiss Prot

Q6UXN8

Host

Mouse

Species Reactivity

Human

Reactivity

CLEC9A|DNGR1

Immunogen

RBL-2H3 cells expressing human DNGR-1 fused to an HA epitope

Target Antigen

CLEC9A | DNGR1

Clonality

Monoclonal

Clone

8F9

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |IF (published)

Positive Control

MCF-7 cells (FACS/IF).

Stability

2 years

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

27 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. J Clin Invest (2008) 118(6):2098-2110. (IF, Flow) Clinical Translational Immunol (2016) 5:e57. (Flow)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2a, kappa

Species

Mus musculus (mouse)

Classification

PBS, no BSA, no sodium azide (CAS 26628-22-8)

Conjugate

Purified, BSA-free