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Product details

MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL

Catalog number BNCB3085-500

Price for BNCB3085-500

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Size / count 1x 500 µL

About this product

The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number
BNCB3085-500
Size / count
1x 500 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9007-83-4
Synonyms
DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC5; HSAP; MSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; MutS-alpha 160kDa subunit; p160; Sperm associated protein
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
MSH6
Gene ID
2956
NCBI Gene ID
445052
UniProt
P52701
Swiss Prot
P52701
Host
Mouse
Species Reactivity
Human
Reactivity
MSH6
Immunogen
Recombinant fragment of human MSH6 protein (around aa 374-540) (exact sequence is proprietary)
Target Antigen
MSH6
Clonality
Monoclonal
Clone
MSH6/3085
Type
Primary
Source
Animal
Origin
Animal
Applications
IF (verified) |IHC, FFPE (verified) |WB (verified)
Positive Control
HCT116, MCF-7, A431 or HeLa cells. Colon Carcinoma.
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
85 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2b, kappa
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
Biotin

Frequently Asked Questions

What is the catalog number for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL?

The catalog number for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL is BNCB3085-500.

What sizes are available for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL?

MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL in stock?

MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL?

MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL?

The safety data sheet for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029a061270361e1018a9/msds/bncb3085-500.pdf.

What is MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), Biotin conjugate, 0.1mg/mL used for?

The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacter

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

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