MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL

Catalog number BNUB3085-100

Price for BNUB3085-100

Size / count 1x 100 µL

About this product

The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUB3085-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC5; HSAP; MSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; MutS-alpha 160kDa subunit; p160; Sperm associated protein
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: MSH6
Gene ID: 2956
NCBI Gene ID: 445052
UniProt: P52701
Swiss Prot: P52701
Host: Mouse
Species Reactivity: Human
Reactivity: MSH6
Immunogen: Recombinant fragment of human MSH6 protein (around aa 374-540) (exact sequence is proprietary)
Target Antigen: MSH6
Clonality: Monoclonal
Clone: MSH6/3085
Type: Primary
Source: Animal
Origin: Animal
Applications: IF (verified) |IHC, FFPE (verified) |WB (verified)
Positive Control: HCT116, MCF-7, A431 or HeLa cells. Colon Carcinoma.
Stability: 2 years
Concentration: 0.2 mg/mL
Buffer: PBS, 0.05% BSA, 0.05% azide
Molecular Weight: 85 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Classification: PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Purified, with BSA

Frequently Asked Questions

What is the catalog number for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL?

The catalog number for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL is BNUB3085-100.

What sizes are available for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL?

MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL is available in the following size(s): 1x 100 µL.

Is MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL in stock?

MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL?

MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL is manufactured by Biotium.

What is the estimated delivery time for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL?

Estimated delivery time for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL?

The safety data sheet for MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0298061270361e100eaa/msds/bnub3085-100.pdf.

What is MSH6 (DNA Mismatch Repair Protein) (MSH6/3085), 0.2mg/mL used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.