OX40 / CD134/ TNFRSF4 (Immuno-Oncology Target) (OX40/3108), 0.2mg/mL

About this product

ThisMAb recognizes a protein of 43 kDa, identified as OX40, which is also known as CD134. OX40 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. It is expressed on activated T lymphocytes, hematopoietic precursor cells and fibroblasts. It functions as a T cell co-stimulatory receptor when bound by OX40 Ligand/TNFSF4 that is expressed by antigen presenting cells. OX40 thereby plays roles in T-cell activation as well as the regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells. OX40 is upregulated at the sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUB3108-100

Size / count

1x 100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

ACT35; CD134; Lymphoid activation antigen ACT35; OX40; TAX transcriptionally-activated glycoprotein 1 receptor; TNFRSF4 (Tumor necrosis factor receptor superfamily member 4)

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

TNFRSF4

Gene ID

7293

NCBI Gene ID

129780

UniProt

P43489

Swiss Prot

P43489

Host

Mouse

Species Reactivity

Chimpanzee, Human

Reactivity

CD134, |OX40|TNFRSF4

Immunogen

Recombinant fragment of human OX40 (CD134) protein (around aa 59-205) (exact sequence is proprietary)

Target Antigen

CD134, | OX40 | TNFRSF4

Clonality

Monoclonal

Clone

OX40/3108

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow (verified) |IF (verified) |IHC, FFPE (verified)

Positive Control

MOLT-4 cells. Human peripheral blood leukocytes (hPBL). Human tonsil tissue (IHC).

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

43 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2c, kappa

Classification

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

Conjugate

Purified, with BSA