TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL

Catalog number BNC683113-500

Price for BNC683113-500

Size / count 1x 500 µL

About this product

TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4 Th1 and CD8 Tc1) but not on helper T cells (CD4 Th2 and CD8 Tc2) . In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC683113-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: CD366; HAVR2; Hepatitis A virus cellular receptor 2 (HAVCR2) ; Kidney injury molecule 3 (KIM3) ; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM3; TIMD3
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: HAVCR2
Gene ID: 84868
NCBI Gene ID: 710500
UniProt: Q8TDQ0
Swiss Prot: Q8TDQ0
Host: Mouse
Species Reactivity: Human
Reactivity: CD366|HAVCR2|TIM3
Immunogen: Recombinant fragment of human TIM3 protein (around aa 22-202) (exact sequence is proprietary)
Target Antigen: CD366 | HAVCR2 | TIM3
Clonality: Monoclonal
Clone: TIM3/3113
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: PC3, BT474, HepG2, HDLM-2 or Daudi cells. Tonsil, lymph node or spleen.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 60 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2a, kappa
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF568

Frequently Asked Questions

What is the catalog number for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL?

The catalog number for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL is BNC683113-500.

What sizes are available for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL?

TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL in stock?

TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL?

TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL?

Estimated delivery time for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL?

The safety data sheet for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029a061270361e10145c/msds/bnc683113-500.pdf.

What is TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF568 conjugate, 0.1mg/mL used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.