ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL

Catalog number BNC883260-500

Price for BNC883260-500

Size / count 1x 500 µL

About this product

This MAb recognizes a protein of 36 kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2. 4, 3. 0, and 7. 0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1. 1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC883260-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: B7 homolog 2 (B7H2) ; B7 like protein Gl50; B7 related protein 1 (B7RP1) ; CD275; CD275 antigen; GL50; ICOS LG; ICOS ligand (ICOSL) ; Inducible T cell co stimulator ligand; LICOS; Transmembrane protein B7 H2 ICOS ligand
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: ICOSLG
Gene ID: 23308
NCBI Gene ID: 14155
UniProt: O75144
Swiss Prot: O75144
Host: Mouse
Species Reactivity: Human
Reactivity: B7RP-1|ICOS Ligand|ICOS-L
Immunogen: Recombinant fragment of human ICOSLG (B7RP-1) protein (around aa 23-149) (exact sequence is proprietary)
Target Antigen: B7RP-1 | ICOS Ligand | ICOS-L
Clonality: Monoclonal
Clone: ICOSL/3260
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: HL60, HuT78 and HUVEC cells. Prostate or Colon Carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 36 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF488A

Frequently Asked Questions

What is the catalog number for ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL?

The catalog number for ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL is BNC883260-500.

What sizes are available for ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL?

ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL in stock?

ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL?

ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL?

Estimated delivery time for ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL?

The safety data sheet for ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029e061270361e102f01/msds/bnc883260-500.pdf.

What is ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF488A conjugate, 0.1mg/mL used for?

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.