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Product details
Catalog number BNUB3325-500
Price for BNUB3325-500
Size / count 1x 500 µL
Please note that this antibody is a recombinant Rabbit version of original anti-histone H1 antibody (Clone AE-4) . Because the variable heavy (VH) and variable light (VL) domains are the same, recombinant antibody has the same exact reactivity as the original AE-4 MAb. There are several advantages of producing a recombinant version of a monoclonal antibody. For example, a recombinant antibody is a pure preparation of active immunoglobulin with no contaminating non-functional intact Ig or free light/heavy chains. Secondly, antibody can always be produced, even if hybridoma line is lost. Moreover, it adds the flexibility of converting the antibody to any species, isotype or format. Eukaryotic histones are basic and water-soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. This antibody is extensively used as a pan-nuclear marker. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Histone H1 (Pan Nuclear Marker) (AE-4), 0.2mg/mL is BNUB3325-500.
Histone H1 (Pan Nuclear Marker) (AE-4), 0.2mg/mL is available in the following size(s): 1x 500 µL.
Histone H1 (Pan Nuclear Marker) (AE-4), 0.2mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Histone H1 (Pan Nuclear Marker) (AE-4), 0.2mg/mL is manufactured by Biotium.
Estimated delivery time for Histone H1 (Pan Nuclear Marker) (AE-4), 0.2mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Histone H1 (Pan Nuclear Marker) (AE-4), 0.2mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029a061270361e1014bb/msds/bnub3325-500.pdf.
Please note that this antibody is a recombinant Rabbit version of original anti-histone H1 antibody (Clone AE-4) . Because the variable heavy (VH) and variable light (VL) domains are the same, recombinant antibody has the same exact reactivity as the original AE-4 MAb. There are several advantages o
Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.
Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.
Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.
