CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL

Catalog number BNC473340-100

Price for BNC473340-100

Size / count 1x 100 µL

About this product

CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin aM combines with the Integrin '2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3) . Integrin aM/'2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b andCD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC473340-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: CD18; CD49d; Cell surface glycoprotein MAC-1 subunit alpha; Complement Component Receptor 3 Alpha; CR3 Alpha Chain (CR3A) ; Integrin alpha-M; Integrin beta 2 alpha subunit; Leukocyte adhesion receptor MO1; Ly-40; MAC1A; Macrophage antigen alpha polypeptide; MO1A; Neutrophil adherence receptor alpha M subunit
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: ITGAM
Gene ID: 3684
NCBI Gene ID: 172631
UniProt: P11215
Swiss Prot: P11215
Host: Mouse
Species Reactivity: Human
Reactivity: CD11b|MAC-1
Immunogen: Recombinant fragment (around aa941-1074) of human ITGAM protein (exact sequence is proprietary)
Target Antigen: CD11b | MAC-1
Clonality: Monoclonal
Clone: ITGAM/3340
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified) |WB (verified)
Positive Control: Monocytes & granulocytes. Lymph nodes, spleen and tonsil (IHC).
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 95 kDa & 170 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2a, kappa
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF647

Frequently Asked Questions

What is the catalog number for CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL?

The catalog number for CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL is BNC473340-100.

What sizes are available for CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL?

CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL in stock?

CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL?

CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL?

The safety data sheet for CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02b5061270361e10b3c2/msds/bnc473340-100.pdf.

What is CD11b / MAC-1 (Microglial Marker) (ITGAM/3340), CF647 conjugate, 0.1mg/mL used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.