NKX3.1 (Metastatic Prostate Adenocarcinoma Marker) (NKX3.1/3348), CF405S conjugate, 0.1mg/mL

About this product

NKX3. 1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21. 2, which frequently undergoes a loss of heterozygosity. NKX3. 1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3. 1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3. 1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC043348-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

NK3 Transcription Factor Related; Locus 1; NK Homeobox (Drosophila) ; Family 3; A; NK3 Transcription Factor Homolog A; NK Homeobox; Family 3; A; Homeobox Protein Nkx-3.1; BAPX2; NKX3

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

NKX3-1

Gene ID

4824

NCBI Gene ID

55999

UniProt

Q99801

Swiss Prot

Q99801

Host

Mouse

Species Reactivity

Human

Reactivity

NKX3.1

Immunogen

Recombinantfragment (around aa 92-224) of humanNKX3.1 protein (exact sequence is proprietary)

Target Antigen

NKX3.1

Clonality

Monoclonal

Clone

NKX3.1/3348

Type

Primary

Source

Animal

Origin

Animal

Applications

IHC, FFPE (verified)

Positive Control

Highly expressed in the prostate and at a lower level in the testis.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

35 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2b, kappa

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF405S