- Home
- Shop
- New Categories
- New Blog
- Contact Us
- Cart
- Login
- Register
Select the image to view it full size.
Product details
Catalog number BNC403812-500
Price for BNC403812-500
Size / count 1x 500 µL
Recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2. 1. 1. 45) . It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5, 10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF640R conjugate, 0.1mg/mL is BNC403812-500.
Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.
Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF640R conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0299061270361e101091/msds/bnc403812-500.pdf.
Recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2. 1. 1. 45) . It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of anti
Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.
If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.
The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.
