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Product details
Catalog number BNC473812-100
Price for BNC473812-100
Size / count 1x 100 µL
Recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2. 1. 1. 45) . It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5, 10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is BNC473812-100.
Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.
Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02ab061270361e1078a3/msds/bnc473812-100.pdf.
Recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2. 1. 1. 45) . It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of anti
The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.
As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.
Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.
