Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL

Catalog number BNC473812-500

Price for BNC473812-500

Size / count 1x 500 µL

About this product

Recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2. 1. 1. 45) . It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5, 10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC473812-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DTMP synthase; TMS; TS; TSase; TYMS protein; Tyms thymidylate synthetase
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TYMS
Gene ID: 7298
NCBI Gene ID: 369762
UniProt: P04818
Swiss Prot: P04818
Host: Mouse
Species Reactivity: Human
Reactivity: Thymidylate Synthase
Immunogen: Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)
Target Antigen: Thymidylate Synthase
Clonality: Recombinant Monoclonal
Clone: RTYMS/1884
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, intracellular (verified) |IF (verified)
Positive Control: MOLT4; Ramos, 5-FU-resistant colon carcinoma cell lines (NCI H630R10, NCI H630R1); 5-FU-resistant breast cancer cell lines, MCF-Ad5 and MCF-Ad10. Testicular carcinomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 36 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF647

Frequently Asked Questions

What is the catalog number for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL?

The catalog number for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is BNC473812-500.

What sizes are available for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL?

Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL in stock?

Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL?

Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL?

The safety data sheet for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02b5061270361e10b276/msds/bnc473812-500.pdf.

What is Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF647 conjugate, 0.1mg/mL used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.