Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL

Catalog number BNC943812-100

Price for BNC943812-100

Size / count 1x 100 µL

About this product

Recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2. 1. 1. 45) . It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5, 10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC943812-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DTMP synthase; TMS; TS; TSase; TYMS protein; Tyms thymidylate synthetase
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TYMS
Gene ID: 7298
NCBI Gene ID: 369762
UniProt: P04818
Swiss Prot: P04818
Host: Mouse
Species Reactivity: Human
Reactivity: Thymidylate Synthase
Immunogen: Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)
Target Antigen: Thymidylate Synthase
Clonality: Recombinant Monoclonal
Clone: RTYMS/1884
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, intracellular (verified) |IF (verified)
Positive Control: MOLT4; Ramos, 5-FU-resistant colon carcinoma cell lines (NCI H630R10, NCI H630R1); 5-FU-resistant breast cancer cell lines, MCF-Ad5 and MCF-Ad10. Testicular carcinomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 36 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF594

Frequently Asked Questions

What is the catalog number for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL?

The catalog number for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL is BNC943812-100.

What sizes are available for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL?

Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL in stock?

Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL?

Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL?

Estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL?

The safety data sheet for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a6061270361e105bf1/msds/bnc943812-100.pdf.

What is Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), CF594 conjugate, 0.1mg/mL used for?

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.