Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL

Catalog number BNUB3812-100

Price for BNUB3812-100

Size / count 1x 100 µL

About this product

Recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2. 1. 1. 45) . It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5, 10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUB3812-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DTMP synthase; TMS; TS; TSase; TYMS protein; Tyms thymidylate synthetase
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TYMS
Gene ID: 7298
NCBI Gene ID: 369762
UniProt: P04818
Swiss Prot: P04818
Host: Mouse
Species Reactivity: Human
Reactivity: Thymidylate Synthase
Immunogen: Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)
Target Antigen: Thymidylate Synthase
Clonality: Recombinant Monoclonal
Clone: RTYMS/1884
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, intracellular (verified) |IF (verified)
Positive Control: MOLT4; Ramos, 5-FU-resistant colon carcinoma cell lines (NCI H630R10, NCI H630R1); 5-FU-resistant breast cancer cell lines, MCF-Ad5 and MCF-Ad10. Testicular carcinomas.
Stability: 2 years
Concentration: 0.2 mg/mL
Buffer: PBS, 0.05% BSA, 0.05% azide
Molecular Weight: 36 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Classification: PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Purified, with BSA

Frequently Asked Questions

What is the catalog number for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL?

The catalog number for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL is BNUB3812-100.

What sizes are available for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL?

Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL is available in the following size(s): 1x 100 µL.

Is Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL in stock?

Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL?

Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL is manufactured by Biotium.

What is the estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL?

Estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL?

The safety data sheet for Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a5061270361e10569b/msds/bnub3812-100.pdf.

What is Thymidylate Synthase (5-FU Resistance Marker) (rTYMS/1884), 0.2mg/mL used for?

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.