SynGAP Recombinant Rabbit Monoclonal Antibody [JE57-79]

Catalog number HA721860

Price for HA721860

Size / count 100 µL

About this product

SynGAP1 is a complex protein with several functions that may be regulated temporally via complex isoforms.[8] A well-documented function of SynGAP1 involves NMDA receptor-mediated synaptic plasticity and membrane insertion of AMPA receptors through the suppression of upstream signaling pathways. However, SynGAP1 has also been shown to function cooperatively with Unc51.1 in axon formation. One way SynGAP1 affects these processes is through the MAP kinase signaling pathway by attenuation of Ras signalling. However, alternative splicing and multiple translational start sites have been shown to cause opposing effects, illustrating the importance of multiple functional domains that reside within the c- and n-termini. For example, the expression of an α1 or α2 c-terminal variant of SynGAP1 will either increase or decrease synaptic strength, respectively. Overall, SynGAP1 is essential for development and survival, which is evident as knockout mice die perinatally.

Specifications

Catalog number: HA721860
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: DKFZp761G1421 antibody KIAA1938 antibody MRD5 antibody Neuronal RasGAP antibody OTTHUMP00000064825 antibody p135 SynGAP antibody Ras GTPase activating protein SynGAP antibody Ras GTPase-activating protein SynGAP antibody RASA 1 antibody RASA 5 antibody RASA1 antibody RASA5 antibody SYGP1_HUMAN antibody Synaptic Ras GAP 1 antibody Synaptic Ras GTPase activating protein 1 antibody Synaptic Ras GTPase activating protein 1 homolog antibody Synaptic Ras GTPase activating protein 135kDa antibody Synaptic Ras GTPase activating protein antibody Synaptic Ras GTPase-activating protein 1 antibody Synaptic Ras-GAP 1 antibody SYNGAP 1 antibody SYNGAP1 antibody
Abbreviation: SYNGAP1
Swiss Prot: F6SEU4 Mouse, Q9QUH6 Rat
Cellular Locus: Cytosol, dendritic shaft, glutamatergic synapse, plasma membrane, postsynaptic density.
Host: Rabbit
Species Reactivity: Mouse, Rat
Immunogen: Synthetic peptide within Human SynGAP aa 1,294-1,343 / 1,343.
Isotype: IgG
Clone: JE57-79
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, IF-Tissue
Positive Control: Mouse brain tissue lysate, mouse hippocampus tissue lysate, rat brain tissue lysate, rat hippocampus tissue lysate, mouse brain tissue, mouse hippocampus tissue, rat brain tissue, rat hippocampus tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IHC-P: 1:500-1:2,000 ;IF-Tissue: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 148 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for SynGAP Recombinant Rabbit Monoclonal Antibody [JE57-79]?

The catalog number for SynGAP Recombinant Rabbit Monoclonal Antibody [JE57-79] is HA721860.

What sizes are available for SynGAP Recombinant Rabbit Monoclonal Antibody [JE57-79]?

SynGAP Recombinant Rabbit Monoclonal Antibody [JE57-79] is available in the following size(s): 100 µL.

Is SynGAP Recombinant Rabbit Monoclonal Antibody [JE57-79] in stock?

SynGAP Recombinant Rabbit Monoclonal Antibody [JE57-79] is currently made to order / not held in immediate stock. Contact us for lead time.

What is SynGAP Recombinant Rabbit Monoclonal Antibody [JE57-79] used for?

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.