RNase L Recombinant Rabbit Monoclonal Antibody [JE36-11]

Catalog number HA722221

Price for HA722221

Size / count 100 µL

About this product

Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease, is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral). RNase L is an enzyme that in humans is encoded by the RNASEL gene. This gene encodes a component of the interferon-regulated 2'-5'oligoadenylate (2'-5'A) system that functions in the antiviral and antiproliferative roles of interferons. RNase L is activated by dimerization, which occurs upon 2'-5'A binding, and results in cleavage of all RNA in the cell. This can lead to activation of MDA5, an RNA helicase involved in the production of interferons.

Specifications

Catalog number: HA722221
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: 2 5A dependent ribonuclease antibody 2 5A dependent RNase antibody 2' 5' oligoisoadenylate synthetase dependent antibody 2-5A-dependent ribonuclease antibody 2-5A-dependent RNase antibody DKFZp781D08126 antibody Interferon induced 2 5A dependent RNase antibody MGC104972 antibody MGC133329 antibody PRCA 1 antibody PRCA1 antibody Ribonuclease 4 antibody Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) antibody Ribonuclease L antibody Ribonuclease4 antibody RibonucleaseL antibody RN5A_HUMAN antibody RNase L antibody Rnasel antibody RNS 4 antibody RNS4 antibody
Abbreviation: RNASEL, RNS4
Swiss Prot: Q05823 Human
Cellular Locus: Cytoplasm, Mitochondrion.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human RNase L aa 492-741 / 741.
Isotype: IgG
Clone: JE36-11
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: THP-1 cell lysate, THP-1 treated with 20ng/mL IFN-γ for 48 hours cell lysate, 293T cell lysate, HeLa cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 84 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for RNase L Recombinant Rabbit Monoclonal Antibody [JE36-11]?

The catalog number for RNase L Recombinant Rabbit Monoclonal Antibody [JE36-11] is HA722221.

What sizes are available for RNase L Recombinant Rabbit Monoclonal Antibody [JE36-11]?

RNase L Recombinant Rabbit Monoclonal Antibody [JE36-11] is available in the following size(s): 100 µL.

Is RNase L Recombinant Rabbit Monoclonal Antibody [JE36-11] in stock?

RNase L Recombinant Rabbit Monoclonal Antibody [JE36-11] is currently made to order / not held in immediate stock. Contact us for lead time.

What is RNase L Recombinant Rabbit Monoclonal Antibody [JE36-11] used for?

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.