Human IL-2 Receptor alpha Recombinant Rabbit Monoclonal Antibody [PSH05-65] - BSA and Azide free (Capture)

About this product

Interleukin-2 receptor alpha chain (also called CD25) is the human protein encoded by the IL2RA gene. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes. IL2RA is expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, mastocytosis and tumor infiltrating lymphocytes. It functions as the receptor for HTLV-1 and is consequently expressed on neoplastic cells in adult T cell lymphoma/leukemia. Its soluble form, called sIL-2R may be elevated in these diseases and is occasionally used to track disease progression. Infection by the protozoan Trypanosoma cruzi causes Chagas disease, characterized by a reduction in the amount of IL2RA expressed on the surface of immune cells. This leads to chronic immune suppression, becoming increasingly severe over the course of many years and ultimately resulting in death if left untreated.

Specifications

Catalog number

HA722385

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Interleukin 2 receptor alpha chain antibody CD25 antibody CD25 antigen antibody IDDM10 antibody IL 2 receptor alpha subunit antibody IL-2 receptor subunit alpha antibody IL-2-RA antibody IL-2R subunit alpha antibody IL2 RA antibody IL2 Receptor alpha antibody IL2-RA antibody IL2R antibody IL2R, alpha chain antibody IL2RA antibody IL2RA_HUMAN antibody IMD41 antibody Interleukin 2 receptor alpha antibody Interleukin 2 receptor antibody Interleukin-2 receptor subunit alpha antibody p55 antibody t-cell growth factor receptor antibody TAC antibody TAC antigen antibody TCGFR antibody

Abbreviation

Interleukin-2 receptor subunit alpha IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA TAC antigen p55 CD25 IL2RA

Swiss Prot

P01589 Human

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within human IL-2 Receptor alpha aa 22-240 (Extracellular).

Isotype

IgG

Clone

PSH05-65

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

ELISA (Cap)

Positive Control

Recombinant standard Human IL2RA protein (HA210771).

Concentration

1 mg/mL

Dilution

ELISA (Cap): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH05-66] to Human IL2RA (Detector) (HA722386) and recombinant standard Human IL2RA protein (HA210771). The reference range value is 8.2-2000pg/ml.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4).

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes