SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified)

Catalog number SPN-C522c-100mg

Discontinued

Price for SPN-C522c-100mg

Size / count 100 mg

This variant is discontinued and cannot be added to your cart.

About this product

SARS-CoV-2 Spike Trimer, His Tag (BA.3/Omicron) (SPN-C522c) is expressed from human 293 cells (HEK293). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.3; GISAID clade: GRA; Nextstrain clade: 21M). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.

Specifications

Catalog number: SPN-C522c-100mg
Size / count: 100 mg
Dry ice: Yes
Hazardous: No
Discontinued: Yes
Background: It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Specifications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 137.8 kDa. The protein migrates as 160-200 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Host: HEK 293
Target: Spike protein
Conjugation: Unconjugated
Tag: C-10×His
Source: SARS-CoV-2
Stability: The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin: 1.0 EU per μg
Purity: 95%
Bioactivity: Immobilized SARS-CoV-2 Spike Trimer, His Tag (BA.3/Omicron) (Cat. No. SPN-C522c) at 1 μg/mL (100 μL/well) can bind Human ACE2, Fc Tag (Cat. No. AC2-H5257) with a linear range of 2-31 ng/mL (QC tested).
Format: Liquid
Buffer: 0.1 M Sodium citrate, pH5.5
Molecular Weight: 137.8 kDa
Shipping Conditions: Dry ice
Storage Conditions: -70°C

Frequently Asked Questions

What is the catalog number for SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified)?

The catalog number for SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) is SPN-C522c-100mg.

Is SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) in stock?

SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) is currently made to order / not held in immediate stock. Contact us for lead time.

Are there any special shipping requirements for SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified)?

SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) is requires dry ice shipping.

Who manufactures SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified)?

SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) is manufactured by CRB.

What is the estimated delivery time for SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified)?

Estimated delivery time for SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) is approximately 10 business day(s), depending on your location.

What is SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) used for?

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.