Axin1 Recombinant Rabbit Monoclonal Antibody [PSH03-00]

Catalog number HA721919

Price for HA721919

Size / count 100 µL

About this product

Axin1 (Axis inhibition protein 1) and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin and promotes the GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin . Upon stimulation of cells with Wnt, Axin1 is recruited to the membrane by phosphorylated LRP5/6, a process that is believed to be crucial for activation of Wnt signaling . In addition to its role in the Wnt signaling pathway, Axin1 forms a complex with MEKK1 and activates c-Jun amino-terminal kinase (JNK/SAPK) . Axin2 (also known as Conductin or Axil) can functionally substitute for Axin1 in mice . Axin2 itself is a direct target of the Wnt signaling pathway and therefore serves to control the duration and/or intensity of Wnt signaling through a negative feedback loop .

Specifications

Catalog number: HA721919
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: AI316800 antibody AXIN antibody Axin 1 antibody Axin-1 antibody axin1 antibody AXIN1_HUMAN antibody Axis inhibition protein 1 antibody Axis Inhibitor 1 antibody Fu antibody fused antibody Fused, mouse, homolog of antibody hAxin antibody Kb antibody Ki antibody kinky antibody knobbly antibody MGC132911 antibody MGC52315 antibody PPP1R49 antibody Protein Fused antibody Protein phosphatase 1 regulatory subunit 49 antibody
Abbreviation: Axis inhibition protein 1 (hAxin)
Swiss Prot: O15169 Human
Cellular Locus: Cytoplasm. Nucleus. Membrane. Cell membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within Human Axin1 aa 1-400 / 862.
Isotype: IgG
Clone: PSH03-00
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P
Positive Control: SW480 cell lysate, HeLa cell lysate, 293T cell lysate, K-562 cell lysate, Huh7 cell lysate, human colon cancer tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IHC-P: 1:500-1:2,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 95.6 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Axin1 Recombinant Rabbit Monoclonal Antibody [PSH03-00]?

The catalog number for Axin1 Recombinant Rabbit Monoclonal Antibody [PSH03-00] is HA721919.

What sizes are available for Axin1 Recombinant Rabbit Monoclonal Antibody [PSH03-00]?

Axin1 Recombinant Rabbit Monoclonal Antibody [PSH03-00] is available in the following size(s): 100 µL.

Is Axin1 Recombinant Rabbit Monoclonal Antibody [PSH03-00] in stock?

Axin1 Recombinant Rabbit Monoclonal Antibody [PSH03-00] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Axin1 Recombinant Rabbit Monoclonal Antibody [PSH03-00] used for?

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.