RIPK2 Recombinant Rabbit Monoclonal Antibody [JE51-90]

About this product

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Also plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. Plays a role in the inactivation of RHOA in response to NGFR signaling. Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.

Specifications

Catalog number

HA721300

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CARD 3 antibody CARD carrying kinase antibody CARD containing ICE associated kinase antibody CARD containing IL 1 beta ICE kinase antibody CARD containing IL1 beta ICE kinase antibody CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase antibody CARD containing interleukin 1 beta converting enzyme associated kinase antibody CARD-containing IL-1 beta ICE-kinase antibody CARD-containing interleukin-1 beta-converting enzyme-associated kinase antibody CARD3 antibody CARDIAK antibody CCK antibody CLARP kinase antibody GIG 30 antibody GIG30 antibody Growth inhibiting gene 30 antibody Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase antibody Receptor interacting protein 2 antibody Receptor interacting serine threonine kinase 2 antibody Receptor interacting serine/threonine protein kinase 2 antibody Receptor-interacting protein 2 antibody Receptor-interacting serine/threonine-protein kinase 2 antibody RICK antibody RIP 2 antibody RIP like interacting CLARP kinase antibody RIP-2 antibody RIP-like-interacting CLARP kinase antibody RIPK 2 antibody Ripk2 antibody RIPK2_HUMAN antibody TNFRSF antibody Tyrosine-protein kinase RIPK2 antibody UNQ277/PRO314/PRO34092 antibody

Abbreviation

Receptor-interacting serine/threonine-protein kinase 2 EC:2.7.11.1 CARD-containing interleukin-1 beta-converting enzyme-associated kinase (CARD-containing IL-1 beta ICE-kinase) RIP-like-interacting CLARP kinase Receptor-interacting protein 2 (RIP-2) Tyrosine-protein kinase RIPK2 RIPK2 CARDIAK, RICK, RIP2 UNQ277/PRO314/PRO34092

Swiss Prot

O43353 Human

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within human RIPK2 aa 500-540.

Isotype

IgG

Clone

JE51-90

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

PC-3M cell lysate, 22Rv1cell lysate, RWPE-1 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 61 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes