CD13 Recombinant Rabbit Monoclonal Antibody [PSH08-48]

About this product

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. AAP is also used by some viruses as a receptor to which these viruses bind to and then enter cells. It is a receptor for human coronavirus 229E, feline coronavirus serotype II (FCoV-II), TGEV, PEDV, canine coronavirus genotype II (CCoV-II) as well as several Deltacoronaviruses.

Specifications

Catalog number

HA722994

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Alanyl (membrane) aminopeptidase antibody Alanyl aminopeptidase antibody Aminopeptidase M antibody Aminopeptidase N antibody AMPN_HUMAN antibody ANPEP antibody AP M antibody AP N antibody AP-M antibody AP-N antibody APN antibody CD 13 antibody CD13 antibody CD13 antigen antibody gp150 antibody hAPN antibody LAP 1 antibody LAP1 antibody Microsomal aminopeptidase antibody Myeloid plasma membrane glycoprotein CD13 antibody p150 antibody PEPN antibody

Abbreviation

Aminopeptidase N, EC:3.4.11.2, AP-N; hAPN, Alanyl aminopeptidase, Aminopeptidase M (AP-M), Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD13, ANPEP, APN, CD13, PEPN

Swiss Prot

P15144 Human

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within human CD13 aa 33-967.

Isotype

IgG

Clone

PSH08-48

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

U-937 cell lysate, PANC-1 cell lysate, HL-60 cell lysate, PANC-1, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:5,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 110 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes