TrkC Recombinant Rabbit Monoclonal Antibody [PSH05-40]

About this product

Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene. TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). As such, TrkC mediates the multiple effects of this neurotrophic factor, which includes neuronal differentiation and survival. The TrkC receptor is part of the large family of receptor tyrosine kinases. A "tyrosine kinase" is an enzyme which is capable of adding a phosphate group to the certain tyrosines on target proteins, or "substrates". A receptor tyrosine kinase is a "tyrosine kinase" which is located at the cellular membrane, and is activated by binding of a ligand via its extracellular domain. Other example of tyrosine kinase receptors include the insulin receptor, the IGF-1 receptor, the MuSK protein receptor, the vascular endothelial growth factor (VEGF) receptor, etc. The "substrate" proteins which are phosphorylated by TrkC include PI3 kinase.

Specifications

Catalog number

HA722269

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

EC 2.7.10.1 antibody ETS related protein neurotrophic receptor tyrosine kinase fusion antibody ETS related protein neurotrophic receptor tyrosine kinase fusion protein antibody ETV6 NTRK3 fusion antibody GP145 TrkC antibody gp145 (trkC) antibody GP145-TrkC antibody GP145TrkC antibody Neurotrophic tyrosine kinase receptor type 3 antibody Neurotrophin 3 receptor antibody NT 3 growth factor receptor antibody NT 3 growth factor receptor precursor antibody NT 3 receptor antibody NT-3 growth factor receptor antibody Ntrk3 antibody NTRK3_HUMAN antibody OTTHUMP00000192915 antibody TRK C antibody Trk-C antibody TRKC antibody TrkC tyrosine kinase antibody Tyrosine kinase receptor C antibody

Abbreviation

NTRK3, TRKC

Swiss Prot

Q16288 Human, Q6VNS1 Mouse, Q03351 Rat

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human TrkC aa 1-429 / 839.

Isotype

IgG

Clone

PSH05-40

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC, IF-Tissue

Positive Control

TT cell lysate, mouse brain tissue lysate, rat brain tissue lysate, TT, human brain tissue, mouse brain tissue, rat brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:100 ;IHC-P: 1:2,000 ;FC: 1:1,000 ;IF-Tissue: 1:200-1:400

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 94 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes