MyD88 Recombinant Rabbit Monoclonal Antibody [PSH05-58]

About this product

Interleukin-1 (IL-1)-induced activation of the NFκB pathway is mediated through the IL-1 receptor and the subsequent phosphorylation of IL-1 receptor-associated kinase (IRAK). The myeloid differentiation protein MyD88 was originally characterized as a protein upregulated in myeloleukemic cells following IL-6-induced growth arrest and terminal differentiation. MyD88 is now known to function as an adaptor protein for the association of IRAK with the IL-1 receptor. MyD88 is functionally homologous to the adaptor protein tube in the Toll signaling pathway of Drosophilia, and both proteins are members of the Toll/IL-1R superfamily. MyD88 contains a characteristic N-terminal death domain that is essential for NFκB activation and an adjacent Toll/IL-1R homology domain (TIR domain). Collectively, these domains enable the protein-protein interactions of MyD88 with IRAK and the IL-1 receptor complex.

Specifications

Catalog number

HA722378

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Mutant myeloid differentiation primary response 88 antibody MYD 88 antibody Myd88 antibody MYD88_HUMAN antibody MYD88D antibody Myeloid differentiation marker 88 antibody Myeloid differentiation primary response 88 antibody Myeloid differentiation primary response gene (88) antibody Myeloid differentiation primary response gene 88 antibody Myeloid differentiation primary response gene antibody Myeloid differentiation primary response protein MyD88 antibody OTTHUMP00000161718 antibody OTTHUMP00000208595 antibody OTTHUMP00000209058 antibody OTTHUMP00000209059 antibody OTTHUMP00000209060 antibody

Abbreviation

MYD88

Swiss Prot

Q99836 Human

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Monkey

Immunogen

Recombinant protein within human MyD88 aa 101-296 / 296.

Isotype

IgG

Clone

PSH05-58

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC, IP

Positive Control

A549 cell lysate, HepG2 cell lysate, MCF7 cell lysate, Jurkat cell lysate, K-562 cell lysate, HL-60 cell lysate, LNCaP cell lysate, SK-Br-3 cell lysate, COS-1 cell lysate, A549, human kidney tissue, human lung cancer tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:500-1:1,000 ;FC: 1:1,000 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 33 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes