Rabbit TIGIT Protein, Fc Tag (MALS verified)

Catalog number TIT-R5259-1mg

Discontinued

Price for TIT-R5259-1mg

Size / count 1 mg

This variant is discontinued and cannot be added to your cart.

About this product

Rabbit TIGIT, Fc Tag (TIT-R5259) is expressed from human 293 cells (HEK293). It contains AA Ala 16 - Pro 142 (Accession # G1SLC1).

Specifications

Catalog number: TIT-R5259-1mg
Size / count: 1 mg
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Specifications: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.4 kDa. The protein migrates as 45-50 kDa under reducing (R) condition, and 90-116 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Expression Region: Ala 16 - Pro 142
Host: HEK 293
Target: TIGIT
Conjugation: Unconjugated
Tag: C-Fc
Source: Rabbit
Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin: 1.0 EU per μg
Purity: 95%
Bioactivity: Immobilized Human Nectin-2, His Tag (Cat. No. PV2-H52E2) at 5 μg/mL (100 μL/well) can bind Rabbit TIGIT, Fc Tag (Cat. No. TIT-R5259) with a linear range of 5-78 ng/mL (QC tested).
Format: Powder
Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
Additives: Trehalose
Molecular Weight: 40.4 kDa
Shipping Conditions: Room Temperature
Storage Conditions: -20°C

Frequently Asked Questions

What is the catalog number for Rabbit TIGIT Protein, Fc Tag (MALS verified)?

The catalog number for Rabbit TIGIT Protein, Fc Tag (MALS verified) is TIT-R5259-1mg.

Is Rabbit TIGIT Protein, Fc Tag (MALS verified) in stock?

Rabbit TIGIT Protein, Fc Tag (MALS verified) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Rabbit TIGIT Protein, Fc Tag (MALS verified)?

Rabbit TIGIT Protein, Fc Tag (MALS verified) is manufactured by CRB.

What is the estimated delivery time for Rabbit TIGIT Protein, Fc Tag (MALS verified)?

Estimated delivery time for Rabbit TIGIT Protein, Fc Tag (MALS verified) is approximately 10 business day(s), depending on your location.

What is Rabbit TIGIT Protein, Fc Tag (MALS verified) used for?

Rabbit TIGIT, Fc Tag (TIT-R5259) is expressed from human 293 cells (HEK293). It contains AA Ala 16 - Pro 142 (Accession # G1SLC1).

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.