Mouse FGF R4 / CD334 Protein, His Tag

About this product

Mouse FGF R4, His Tag (FG4-M52Ha) is expressed from human 293 cells (HEK293). It contains AA Leu 17 - Asp 366 (Accession # Q03142-1).

Specifications

Catalog number

FG4-M52Ha-100ug

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Fibroblast growth factor receptor 4(FGFR4) is also known as CD334, JTK2, hydroxyaryl-protein kinase, TKF, protein-tyrosine kinase . The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development.The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 40.7 kDa. The protein migrates as 55-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Expression Region

Leu 17 - Asp 366

Host

HEK 293

Target

FGF R4

Conjugation

Unconjugated

Tag

C-10×His

Source

Mouse

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Mouse FGF R4, His Tag (Cat. No. FG4-M52Ha) at 2 μg/mL (100 μL/well) can bind Human FGF-9, Fc Tag (Cat. No. FG9-H4267) with a linear range of 0.156-5 μg/mL (QC tested).

Format

Powder

Buffer

PBS, pH7.4

Additives

Trehalose

Molecular Weight

40.7 kDa

Shipping Conditions

Room Temperature

Storage Conditions

-20°C