Canine TSPAN8 Protein, His Tag (MALS verified)

About this product

Canine TSPAN8, His Tag (TS8-C5248) is expressed from human 293 cells (HEK293). It contains AA Lys 110 - His 205 (Accession # A0A8C0S7T2-1).

Specifications

Catalog number

TS8-C5248-1mg

Size / count

1 mg

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Tspan8 is 1 of the 33 mammalian members of the tetraspanin family, composed of transmembrane proteins that organize laterally, together or with other membrane partners such as integrins, to form ‘tetraspanin webs’. These platforms signal within cells to regulate many cellular processes: adhesion, migration, invasion or survival Tspan8 has been implicated in many types of cancer.Overexpression was reported in glioma and colorectal, esophageal, hepatic, gastric and pancreatic carcinoma. Tspan8 exerts a pro-invasive function by controlling cell–cell and cell–matrix interactions through its association with membrane partners such as α6β4 integrin-protein kinase C (PKC)-activated, E-cadherin, EpCAM, claudin-7 and CD44. Moreover, Tspan8 may be a promising new therapeutic target, as Tspan8-specific antibodies were shown to reduce cell motility, block tumor angiogenesis in vivo.

Specifications

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 12.7 kDa. The protein migrates as 17 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Expression Region

Lys 110 - His 205

Host

HEK 293

Target

TSPAN8

Conjugation

Unconjugated

Tag

N-10×His

Source

Canine

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

95%

Format

Powder

Buffer

PBS, pH7.4

Additives

Trehalose

Molecular Weight

12.7 kDa

Shipping Conditions

Room Temperature

Storage Conditions

-20°C