Human CD38&Serum Albumin Protein, His Tag (MALS verified)

About this product

Human CD38&Serum Albumin, His Tag (CDS-H52H7) is expressed from human 293 cells (HEK293) . It contains AA Val 43 - Ile 300 (CD38) & Asp 25 - Leu 609 (Serum Albumin) (Accession # P28907-1 (CD38) & P02768-1 (Serum Albumin) ) .

Specifications

Catalog number

CDS-H52H7-1mg

Size / count

1 mg

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia. serum albumin (SA) is also known as ALB, which is the main protein of plasma and has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs.The main function of SA is the regulation of the colloidal osmotic pressure of blood. As Major zinc transporter in plasma, SA typically binds about 80% of all plasma zinc. A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. Defects in serum albumin can cause familial dysalbuminemic hyperthyroxinemia which is a form of euthyroid hyperthyroxinemia that is due to increased affinity of serum albumin for T4. It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 98.7 kDa. The protein migrates as 105-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

P28907-1 (CD38) & P02768-1 (Serum Albumin)

Expression Region

Val 43 - Ile 300 (CD38) & Asp 25 - Leu 609 (Serum Albumin)

Host

HEK293

Target

CD38 & Serum Albumin

Conjugation

Unconjugated

Tag

C-10xHis

Source

Human

Stability

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Human CD38&Serum Albumin, His Tag (Cat. No. CDS-H52H7) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-CD38 Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

Format

Powder

Buffer

PBS, pH7.4

Additives

Trehalose

Molecular Weight

98.7 kDa

Shipping Conditions

RT

Storage Conditions

-20°C

Package Size

500ug*2

Species

Human