Noggin Rabbit Polyclonal Antibody — image 1 of 3

Product details

Noggin Rabbit Polyclonal Antibody

Catalog number 0805-2

Price for 0805-2

Size / count 100 µL

About this product

Noggin is a signaling molecule that plays an important role in promoting somite patterning in the developing embryo. It is released from the notochord and regulates bone morphogenic protein (BMP4) during development. The absence of BMP4 will cause the patterning of the neural tube and somites from the neural plate in the developing embryo. It also causes formation of the head and other dorsal structures. Noggin function is required for correct nervous system, somite, and skeletal development. Experiments in mice have shown that noggin also plays a role in learning, cognition, bone development, and neural tube fusion. Heterozygous missense mutations in the noggin gene can cause deformities such as joint fusions and syndromes such as multiple synostosis syndrome (SYNS1) and proximal symphalangism (SIM1). SYNS1 is different from SYM1 by causing hip and vertebral fusions. The embryo may also develop shorter bones, miss any skeletal elements, or lack multiple articulating joints. Increased plasma levels of Noggin have been observed in obese mice and in patients with a body mass index over 27. Additionally, it has been shown that Noggin depletion in adipose tissue leads to obesity.

Specifications

Catalog number: 0805-2
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Nog antibody NOGG_HUMAN antibody Noggin antibody SYM 1 antibody SYM1 antibody Symphalangism 1 (proximal) antibody Synostoses (multiple) syndrome 1 antibody SYNS 1 antibody SYNS1 antibody
Abbreviation: Nog
Swiss Prot: Q13253 Human, P97466 Mouse
Cellular Locus: Secreted.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within N-terminal Human Noggin.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, IHC-P
Positive Control: MG-63 cell lysate, Hela cells, HepG2 cells, human liver tissue, mouse liver tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:1,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 26 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Noggin Rabbit Polyclonal Antibody?

The catalog number for Noggin Rabbit Polyclonal Antibody is 0805-2.

What sizes are available for Noggin Rabbit Polyclonal Antibody?

Noggin Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is Noggin Rabbit Polyclonal Antibody in stock?

Noggin Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is Noggin Rabbit Polyclonal Antibody used for?

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.