Beta Catenin Mouse Monoclonal Antibody [A6-F8]

About this product

Catenin beta-1, also known as beta-catenin (β-catenin), is a protein that in humans is encoded by the CTNNB1 gene. Beta-catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. Beta-catenin is widely expressed in many tissues. In cardiac muscle, beta-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. Alterations in the localization and expression levels of beta-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore, genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

Specifications

Catalog number

EM0306

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

β Catenin Beta catenin antibody Beta-catenin antibody Cadherin associated protein antibody Catenin (cadherin associated protein), beta 1, 88kDa antibody Catenin beta 1 antibody Catenin beta-1 antibody CATNB antibody CHBCAT antibody CTNB1_HUMAN antibody CTNNB antibody CTNNB1 antibody DKFZp686D02253 antibody FLJ25606 antibody FLJ37923 antibody OTTHUMP00000162082 antibody OTTHUMP00000165222 antibody OTTHUMP00000165223 antibody OTTHUMP00000209288 antibody OTTHUMP00000209289 antibody

Abbreviation

Catenin beta-1 Beta-catenin CTNNB1 CTNNB OK/SW-cl.35, PRO2286

Swiss Prot

P35222 Human, Q02248 Mouse, Q9WU82 Rat

Cellular Locus

Cytoplasm, Nucleus, Cell junction, Cell membrane, Cytoskeleton, Synapse.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide (KLH-coupled) within human Beta-catenin aa 320-400.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC, IF-Tissue

Positive Control

293T cell lysate, A431 cell lysate, NCCIT cell lysate, SW480 cell lysate, HT-29 cell lysate, HCT 116 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, HT-29, human breast cancer tissue, human colon cancer tissue, human kidney tissue, mouse colon tissue, mouse kidney tissue, rat colon tissue, rat kidney tissue.

Concentration

2 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:100-1:200 ;IHC-P: 1:5,000-1:50,000 ;FC: 1:1,000 ;IF-Tissue: 1:500-1:5,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 85 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No