PD1 Blocking Mouse Monoclonal Antibody [3A11]

About this product

PD-1 blockade works during the effector phase to restore the immune function of T cells in the periphery that have been turned off following extended or high levels of antigen exposure, as in advanced cancer. The ligands for PD-1 can be expressed by tumor cells as well as tumor-infiltrating immune cells. PD-L1 expression on tumor cells varies by tumor type and also within a given tumor type, but appears to be particularly abundant in melanoma, non–small cell lung cancer (NSCLC), and ovarian cancer. In a recent study, PD-L1 expression on tumor cells was shown to be significantly associated with PD-1 expression on TILs, and was locally associated with PD-L2 expression when this ligand was also expressed. In the same study, tumor PD-L1 expression was the single factor most closely correlated with response to anti-PD-1 blockade, whereas PD-L1 expression on TILs was not associated with response. patient response to anti-PD-L1 blockade was strongest when PD-L1 was expressed by tumor-infiltrating immune cells. This antibody recognizing the PD-L1 binding region of PD1.

Specifications

Catalog number

EM1701-17

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

CD279 antibody CD279 antigen antibody hPD 1 antibody hPD l antibody hPD-1 antibody hSLE1 antibody PD 1 antibody PD-1 antibody PD1 antibody PDCD 1 antibody PDCD1 antibody PDCD1_HUMAN antibody Programmed cell death 1 antibody Programmed cell death 1 protein antibody Programmed cell death protein 1 antibody Protein PD 1 antibody Protein PD-1 antibody SLEB2 antibody Systemic lupus erythematosus susceptibility 2 antibody

Swiss Prot

Q15116 Human

Cellular Locus

Membrane.

Host

Mouse

Species Reactivity

Human

Immunogen

Synthetic peptide within human PD1 aa 24 – 170 (Extracellular).

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

ELISA, FC

Positive Control

Jurkat.

Concentration

2 mg/mL

Dilution

ELISA: 1:1,000-1:5,000 ;FC: 1:50-1:100

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 32 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No