Tim3 Mouse Monoclonal Antibody [1E3]

About this product

Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse.

Specifications

Catalog number

EM1701-19

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

CD366 antibody FLJ14428 antibody HAVcr-2 antibody Havcr2 antibody HAVR2_HUMAN antibody Hepatitis A virus cellular receptor 2 antibody Kidney injury molecule 3 antibody KIM 3 antibody KIM3 antibody T cell immunoglobulin and mucin domain containing 3 antibody T cell immunoglobulin mucin 3 antibody T-cell immunoglobulin and mucin domain-containing protein 3 antibody T-cell immunoglobulin mucin family member 3 antibody T-cell immunoglobulin mucin receptor 3 antibody T-cell membrane protein 3 antibody Tim 3 antibody TIM-3 antibody TIM3 antibody TIMD-3 antibody TIMD3 antibody

Abbreviation

HAVcr-2, TIMD-3, TIM-3, HAVCR2, TIM3, TIMD3

Swiss Prot

Q8TDQ0 Human

Cellular Locus

Membrane. Cell junction.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein with Human Tim3 1-89 / 301.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

A549 cell lysate, HepG2 cell lysate, HDLM-2 cell lysate, human colon cancer tissue, human tonsil tissue, 293T, Daudi.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:1,000-1:5,000 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 33 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No