ALDH4A1 Mouse Monoclonal Antibody [7E2]

About this product

Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH4A1 (aldehyde dehydrogenase 4 family member A1), also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), P5CDh, P5CDhL, P5CDhS or ALDH4, is a major enzyme involved in the proline degradation pathway. Localizing to the mitochondrial matrix, ALDH4A1 catalyzes the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate. A mutation in the gene encoding ALDH4A1 results in HPII (hyperprolinemia type II), a disease characterized by an excess of P5C and proline that is associated with mental retardation and seizures.

Specifications

Catalog number

EM1701-74

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

AL4A1_HUMAN antibody aldehyde dehydrogenase 4 antibody aldehyde dehydrogenase 4 family, member A1 antibody Aldehyde dehydrogenase family 4 member A1 antibody Aldehyde dehydrogenase, family 4, subfamily A, member 1 antibody ALDH4 antibody aldh4a1 antibody Delta 1 pyrroline 5 carboxylate dehydrogenase, mitochondrial antibody Delta-1-pyrroline-5-carboxylate dehydrogenase antibody L-glutamate gamma-semialdehyde dehydrogenase antibody mitochondrial antibody mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase antibody P5C dehydrogenase antibody P5CD antibody P5CDh antibody P5CDhL antibody P5CDhS antibody Pyrroline-5-carboxylate dehydrogenase antibody RP11 128M10.1 antibody

Abbreviation

P5C dehydrogenase, ALDH4A1, ALDH4, P5CDH

Swiss Prot

P30038 Human, Q8CHT0 Mouse, P0C2X9 Rat

Cellular Locus

Mitochondrion matrix.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human ALDH4A1 aa 514-563 / 563.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, IF-Cell, IF-Tissue

Positive Control

HepG2 cell lysate, SK-Br-3 cell lysate, human kidney tissue lysate, human liver tissue lysate, mouse liver tissue lysate, rat liver tissue lysate, HepG2, human kidney tissue, human liver tissue, mouse liver tissue, rat liver tissue.

Concentration

2 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IHC-P: 1:1,000 ;IF-Cell: 1:100 ;IF-Tissue: 1:100

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 62 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No