HSPA1L Mouse Monoclonal Antibody [7D1]

About this product

This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria.

Specifications

Catalog number

EM1701-78

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Heat shock 70 kDa protein 1 Hom antibody Heat shock 70 kDa protein 1 like antibody Heat shock 70 kDa protein 1-Hom antibody Heat shock 70 kDa protein 1-like antibody Heat shock 70 kDa protein 1L antibody Heat shock 70kD protein like 1 antibody HS71L_HUMAN antibody HSP70 1L antibody HSP70 HOM antibody HSP70-Hom antibody HSPA1L antibody hum70t antibody Spermatid specific heat shock protein 70 antibody

Abbreviation

Heat shock 70 kDa protein 1L, HSP70-Hom, HSPA1L

Swiss Prot

P34931 Human, P16627 Mouse, P55063 Rat

Cellular Locus

Cytosol. Secreted.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein with Human HSPA1L aa 335-639 / 641.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P

Positive Control

293 cell lysate, mouse testis tissue lysate, rat testis tissue lysate, rat testis tissue, mouse testis tissue.

Concentration

2 mg/mL

Dilution

WB: 1:10,000-1:50,000 ;IHC-P: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 70 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No