IL-31 Mouse Monoclonal Antibody [8-C3] — image 1 of 3

Product details

IL-31 Mouse Monoclonal Antibody [8-C3]

Catalog number EM1701-79

Price for EM1701-79

Size / count 100 µL

About this product

IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.

Specifications

Catalog number: EM1701-79
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: IL 31 antibody IL-31 antibody IL31 antibody IL31_HUMAN antibody Interleukin 31 antibody Interleukin-31 antibody
Abbreviation: IL-31
Swiss Prot: Q6EBC2 Human
Cellular Locus: Secreted.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within Human IL31 aa 1-164 / 164.
Isotype: IgG3
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IHC-P, IF-Cell
Positive Control: A431, LOVO, MCF-7, human tonsil tissue.
Concentration: 2 mg/mL
Dilution: WB: 1:500 ;IF-Cell: 1:100 ;IHC-P: 1:50-1:200
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 18 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for IL-31 Mouse Monoclonal Antibody [8-C3]?

The catalog number for IL-31 Mouse Monoclonal Antibody [8-C3] is EM1701-79.

What sizes are available for IL-31 Mouse Monoclonal Antibody [8-C3]?

IL-31 Mouse Monoclonal Antibody [8-C3] is available in the following size(s): 100 µL.

Is IL-31 Mouse Monoclonal Antibody [8-C3] in stock?

IL-31 Mouse Monoclonal Antibody [8-C3] is currently made to order / not held in immediate stock. Contact us for lead time.

What is IL-31 Mouse Monoclonal Antibody [8-C3] used for?

Is this kit compatible with automated liquid handling platforms?

Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.