HLA Class 1 ABC Mouse Monoclonal Antibody [11C3]

About this product

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

Specifications

Catalog number

EM1801-09

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Antigen presenting molecule antibody HLA class I histocompatibility antigen, A 1 alpha chain antibody HLAA antibody Leukocyte antigen class I A antibody Major histocompatibility complex, class I, A antibody MHC class I antigen HLA A heavy chain antibody AS antibody HLA B protein antibody HLA class I histocompatibility antigen, B alpha chain antibody HLA-B antibody HLA-B histocompatibility type antibody HLAB antibody leukocyte antigen class I-B antibody lymphocyte antigen antibody major histocompatibility complex, class I, B antibody MHC class I antigen GN00104 antibody MHC class I antigen HLA-B heavy chain antibody MHC class I antigen SHCHA antibody MHC Class I HLA heavy chain antibody MHC HLA-B cell surface glycoprotein antibody MHC HLA-B transmembrane glycoprotein antibody SPDA1 antibody 1C07_HUMAN antibody Cw-7 alpha chain antibody D6S204 antibody HLA class I histocompatibility antigen antibody HLA class I histocompatibility antigen, C alpha chain antibody HLA class I histocompatibility antigen, Cw-1 alpha chain antibody HLA JY3 antibody HLA-C antibody HLA-C histocompatibility type antibody HLA-Cw antibody HLA-JY3 antibody HLAC antibody HLC C antibody HLC-C antibody human leukocyte antigen-C alpha chain antibody major histocompatibility antigen HLA-C antibody major histocompatibility complex, class I, C antibody MHC class I antigen antibody MHC class I antigen Cw 1 antibody MHC class I antigen Cw*7 antibody MHC class I antigen heavy chain HLA-C antibody PSORS1 antibody

Abbreviation

HLA-A, HLAA, HLA-B, HLAB, HLA-C, HLAC

Swiss Prot

P04439 Human, P01889 Human, P10321 Human

Cellular Locus

Cell Membrane, Endoplasmic reticulum membrane.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within Human HLA Class 1 ABC aa 1-362 / 362.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

CAL-62 cell lysate, HeLa cell lysate, HepG2 cell lysate, human liver tissue, 293T.

Concentration

2 mg/mL

Dilution

WB:1:500-1:2000 ;IF-Cell:1:50-1:200 ;IHC-P: 1:5,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 40 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No