APE1 Mouse Monoclonal Antibody [12H4] — image 1 of 3

Product details

APE1 Mouse Monoclonal Antibody [12H4]

Catalog number EM1801-13

Price for EM1801-13

Size / count 100 µL

About this product

The role of transcription factors in the regulation of gene expression is well established. Although the activity of these factors can be regulated by phosphorylation, evidence has indicated regulation of DNA binding mediated by changes in reduction-oxidation (redox) status. Mutational analysis has identified a single conserved cysteine residue mapping within the DNA binding domains of Fos and Jun. Chemical oxidation or modification of this cysteine residue inhibits the DNA binding activity of Fos and Jun. A similar mode of regulation has been recently proposed for other nuclear transcription factors. Oxidation is reversible by these compounds or by a cellular redox/DNA repair protein identified originally as Ref-1 (redox factor 1). Ref-1 is identical to a previously characterized DNA repair enzyme designated HAP1, APE or APEX.

Specifications

Catalog number: EM1801-13
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: AP endonuclease 1 antibody AP endonuclease class I antibody AP lyase antibody APE 1 antibody APE antibody APE-1 antibody APEN antibody APEX 1 antibody APEX antibody APEX nuclease (multifunctional DNA repair enzyme) 1 antibody Apex nuclease 1 antibody APEX nuclease antibody APEX1 antibody APEX1_HUMAN antibody Apurinic endonuclease antibody Apurinic-apyrimidinic endonuclease 1 antibody Apurinic/apyrimidinic (abasic) endonuclease antibody Apurinic/apyrimidinic endonuclease 1 antibody Apurinic/apyrimidinic exonuclease antibody APX antibody BAP1 antibody Deoxyribonuclease (apurinic or apyrimidinic) antibody DNA (apurinic or apyrimidinic site) lyase antibody DNA- (apurinic or apyrimidinic site) lyase, mitochondrial antibody EC 4.2.99.18 antibody HAP 1 antibody HAP1 antibody Human Apurinic endonuclease 1 antibody MGC139790 antibody Multifunctional DNA repair enzyme antibody Redox factor 1 antibody Redox factor-1 antibody REF 1 antibody REF 1 protein antibody REF-1 antibody REF1 antibody REF1 protein antibody
Abbreviation: APEN, AP endonuclease 1, APE-1, APEX1, APE, APE1, APEX, APX, HAP1, REF1
Swiss Prot: P27695 Human, P28352 Mouse
Cellular Locus: Nucleus. Endoplasmic reticulum.
Host: Mouse
Species Reactivity: Human, Mouse
Immunogen: Recombinant protein within Human APE1 aa 20-318/318.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IHC-P, FC
Positive Control: HL-60, human liver tissue, human prostate cancer tissue, human kidney tissue, mouse colon tissue, SiHa.
Concentration: 2 mg/mL
Dilution: WB:1:1,000-1:5,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 36 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for APE1 Mouse Monoclonal Antibody [12H4]?

The catalog number for APE1 Mouse Monoclonal Antibody [12H4] is EM1801-13.

What sizes are available for APE1 Mouse Monoclonal Antibody [12H4]?

APE1 Mouse Monoclonal Antibody [12H4] is available in the following size(s): 100 µL.

Is APE1 Mouse Monoclonal Antibody [12H4] in stock?

APE1 Mouse Monoclonal Antibody [12H4] is currently made to order / not held in immediate stock. Contact us for lead time.

What is APE1 Mouse Monoclonal Antibody [12H4] used for?

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.