Cathepsin D Mouse Monoclonal Antibody [13F2] — image 1 of 3

Product details

Cathepsin D Mouse Monoclonal Antibody [13F2]

Catalog number EM1901-15

Price for EM1901-15

Size / count 100 µL

About this product

Cathepsin D is a protein that in humans is encoded by the CTSD gene. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of the CTSD gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. Homozygous deletion of the CTSD gene leads to early lethality in the postnatal phase. Over-expression of cathepsin D stimulates tumorigenicity and metastasis as well as initiation of tumor apoptosis. This protease has been regarded an independent marker of poor prognosis in breast cancer being correlated with the incidence of clinical metastasis. Knock-out of CTSD gene would cause intestinal necrosis and hemorrhage and increase apoptosis in thymus, indicating that cathepsin D is required in certain epithelial cells for tissue remodeling and renewal.

Specifications

Catalog number: EM1901-15
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: CatD antibody CATD_HUMAN antibody Cathepsin D antibody Cathepsin D heavy chain antibody CD antibody Ceroid lipofuscinosis neuronal 10 antibody CLN10 antibody CPSD antibody ctsd antibody Epididymis secretory sperm binding protein Li 130P antibody HEL S 130P antibody Lysosomal aspartyl peptidase antibody Lysosomal aspartyl protease antibody MGC2311 antibody
Abbreviation: CTSD Cathepsin D Cathepsin D light chain Cathepsin D heavy chain
Swiss Prot: P07339 Human, P18242 Mouse, P24268 Rat
Cellular Locus: Lysosome, extracellular space, melanosome.
Host: Mouse
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within Human Cathepsin D aa 1-412 / 412.
Isotype: IgG2b
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IHC-P, FC
Positive Control: MCF7 cell lysate, U-937 cell lysate, SK-Br-3 cell lysate, HepG2 cell lysate, A431 cell lysate, human liver tissue lysate, human lung tissue, human liver tissue, mouse brain tissue, rat cerebellum tissue, SKOV-3.
Concentration: 2 mg/mL
Dilution: WB: 1:1,000-1:5,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity: Protein G affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 45 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Cathepsin D Mouse Monoclonal Antibody [13F2]?

The catalog number for Cathepsin D Mouse Monoclonal Antibody [13F2] is EM1901-15.

What sizes are available for Cathepsin D Mouse Monoclonal Antibody [13F2]?

Cathepsin D Mouse Monoclonal Antibody [13F2] is available in the following size(s): 100 µL.

Is Cathepsin D Mouse Monoclonal Antibody [13F2] in stock?

Cathepsin D Mouse Monoclonal Antibody [13F2] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Cathepsin D Mouse Monoclonal Antibody [13F2] used for?

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.