Cathepsin D Mouse Monoclonal Antibody [13F4] — image 1 of 3

Product details

Cathepsin D Mouse Monoclonal Antibody [13F4]

Catalog number EM1901-17

Price for EM1901-17

Size / count 100 µL

About this product

Cathepsin D is a protein that in humans is encoded by the CTSD gene. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of the CTSD gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. Homozygous deletion of the CTSD gene leads to early lethality in the postnatal phase. Over-expression of cathepsin D stimulates tumorigenicity and metastasis as well as initiation of tumor apoptosis. This protease has been regarded an independent marker of poor prognosis in breast cancer being correlated with the incidence of clinical metastasis. Knock-out of CTSD gene would cause intestinal necrosis and hemorrhage and increase apoptosis in thymus, indicating that cathepsin D is required in certain epithelial cells for tissue remodeling and renewal.

Specifications

Catalog number: EM1901-17
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: CatD antibody CATD_HUMAN antibody Cathepsin D antibody Cathepsin D heavy chain antibody CD antibody Ceroid lipofuscinosis neuronal 10 antibody CLN10 antibody CPSD antibody ctsd antibody Epididymis secretory sperm binding protein Li 130P antibody HEL S 130P antibody Lysosomal aspartyl peptidase antibody Lysosomal aspartyl protease antibody MGC2311 antibody
Abbreviation: CTSD Cathepsin D Cathepsin D light chain Cathepsin D heavy chain
Swiss Prot: P07339 Human
Cellular Locus: Lysosome, extracellular space, melanosome.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within human Cathepsin D aa 10-412.
Isotype: IgG2b
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IHC-P
Positive Control: SK-Br-3 cell lysate, MCF-7 cell lysate, human liver tissue, human liver carcinoma tissue.
Concentration: 2 mg/mL
Dilution: WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200
Purity: Protein G affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 45 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Cathepsin D Mouse Monoclonal Antibody [13F4]?

The catalog number for Cathepsin D Mouse Monoclonal Antibody [13F4] is EM1901-17.

What sizes are available for Cathepsin D Mouse Monoclonal Antibody [13F4]?

Cathepsin D Mouse Monoclonal Antibody [13F4] is available in the following size(s): 100 µL.

Is Cathepsin D Mouse Monoclonal Antibody [13F4] in stock?

Cathepsin D Mouse Monoclonal Antibody [13F4] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Cathepsin D Mouse Monoclonal Antibody [13F4] used for?

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.