Thymidine Phosphorylase Mouse Monoclonal Antibody [A1A10]

About this product

Platelet-derived endothelial cell growth factor (PD-ECGF), which is alternatively designated thymidine phosphorylase or gliostatin, is an angiogenic inducer that potently stimulates the growth of endothelial cells and induces chemotaxis. Biologically active PD-ECGF is a functional dimer that consists of two single polypeptide chains that are expressed in platelets, placenta, foreskin fibroblasts and various squamous cell carcinomas, and they are slowly secreted from the cells. In addition, PD-ECGF is overexpressed in tumor and lesional psoriatic skin and lesional epidermis, indicating that it may play a role in the pathophysiology of psoriasis. Serine residues of PD-ECGF are frequently associated with nucleotide triphosphates, including ATP. In an ATP dependent manner, PD-ECGF is also able to catalyze the reversible phosphorolysis of thymidine to thymine, as it contains thymidine phosphorylase activities.

Specifications

Catalog number

EM1901-22

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ECGF 1 antibody ECGF antibody ECGF1 antibody Endothelial cell growth factor 1 antibody Endothelial cell growth factor 1 platelet derived antibody Endothelial cell growth factor, platelet-derived antibody Gliostatin antibody hPD ECGF antibody MEDPS1 antibody MNGIE antibody MTDPS1 antibody PD ECGF antibody PD-ECGF antibody PDECGF antibody PDEGF antibody Platelet derived endothelial cell growth factor antibody Platelet derived endothelial growth factor antibody Platelet-derived endothelial cell growth factor antibody TdRPase antibody Thymidine phosphorylase antibody TP antibody Tymp antibody TYPH_HUMAN antibody

Abbreviation

Thymidine phosphorylase TP Gliostatin Platelet-derived endothelial cell growth factor PD-ECGF TdRPase TYMP

Swiss Prot

P19971 Human, Q99N42 Mouse, Q5FVR2 Rat

Cellular Locus

Cytosol.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human Thymidine Phosphorylase aa 19-239 / 482.

Isotype

IgG2a

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, FC, IF-Cell

Positive Control

THP-1 cell lysate, A549 cell lysate, A431 cell lysate, HeLa cell lysate, human liver carcinoma tissue, human spleen tissue, SiHa, mouse spleen tissue, rat spleen tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:200-1:10,000 ;FC: 1:50-1:100 ;IF-Cell: 1:50-1:100

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 50 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No