CD40 Mouse Monoclonal Antibody [A1E5]

About this product

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Specifications

Catalog number

EM1901-41

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

AI326936 antibody B cell associated molecule CD40 antibody B cell surface antigen CD40 antibody B cell-associated molecule antibody B-cell surface antigen CD40 antibody Bp50 antibody CD 40 antibody CD40 antibody CD40 antigen (TNF receptor superfamily member 5) antibody CD40 antigen antibody CD40 molecule antibody CD40 molecule, TNF receptor superfamily member 5 antibody CD40 protein antibody CD40 type II isoform antibody CD40L receptor antibody CDw40 antibody GP39 antibody HIGM1 antibody IGM antibody IMD3 antibody MGC9013 antibody Nerve growth factor receptor related B lymphocyte activation molecule antibody OTTHUMP00000031699 antibody OTTHUMP00000031700 antibody p50 antibody T-BAM antibody TBAM antibody TNF receptor superfamily member 5 antibody TNFRSF5 antibody TNR5_HUMAN antibody TRAP antibody Tumor necrosis factor receptor superfamily , member 5 antibody Tumor necrosis factor receptor superfamily member 5 antibody Tumor necrosis factor receptor superfamily member 5 precursor antibody Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a antibody

Abbreviation

Tumor necrosis factor receptor superfamily member 5 B-cell surface antigen CD40 Bp50 CD40L receptor CDw40 CD40 TNFRSF5

Swiss Prot

P25942 Human

Cellular Locus

Cell membrane, secreted.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within human CD40 aa 1-250.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Daudi cell lysates, human spleen tissue, human tonsil tissue, human lymph nodes tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:200-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 31 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No