USP28 Mouse Monoclonal Antibody [A1F8]

Catalog number EM1901-47

Price for EM1901-47

Size / count 100 µL

About this product

Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF (FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells.

Specifications

Catalog number: EM1901-47
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Deubiquitinating enzyme 28 antibody KIAA1515 antibody Ubiquitin carboxyl terminal hydrolase 28 antibody Ubiquitin carboxyl-terminal hydrolase 28 antibody ubiquitin carboxyl-terminal hydrolase 28 variant 1 antibody Ubiquitin specific peptidase 28 antibody Ubiquitin specific processing protease 28 antibody Ubiquitin specific protease 28 antibody Ubiquitin thioesterase 28 antibody Ubiquitin thiolesterase 28 antibody Ubiquitin-specific-processing protease 28 antibody UBP28_HUMAN antibody USP 28 antibody USP28 antibody USP28 protein antibody
Abbreviation: USP28
Swiss Prot: Q96RU2 Human
Cellular Locus: Nucleoplasm.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within Human USP28 aa 509-860 / 1,077.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB
Positive Control: K562 cell lysates, A549 cell lysates.
Concentration: 2 mg/mL
Dilution: WB:1:500-1:2,000
Purity: Protein G affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 122 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for USP28 Mouse Monoclonal Antibody [A1F8]?

The catalog number for USP28 Mouse Monoclonal Antibody [A1F8] is EM1901-47.

What sizes are available for USP28 Mouse Monoclonal Antibody [A1F8]?

USP28 Mouse Monoclonal Antibody [A1F8] is available in the following size(s): 100 µL.

Is USP28 Mouse Monoclonal Antibody [A1F8] in stock?

USP28 Mouse Monoclonal Antibody [A1F8] is currently made to order / not held in immediate stock. Contact us for lead time.

What is USP28 Mouse Monoclonal Antibody [A1F8] used for?

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.