DFNA5 / GSDME Mouse Monoclonal Antibody [A1H3]

About this product

Non-syndromic hearing impairment protein 5 is a protein that in humans is encoded by the DFNA5 gene. Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. The observation that DFNA5 is epigenetically inactivated in a large number of cancers of frequent types (gastric, colorectal, and breast) is another important finding and is in line with its apoptosis-inducing properties. Indeed, if apoptosis is an intrinsic feature of DFNA5, shutting the gene down in tumor cells makes them more susceptible to uncontrolled cellular growth. Moreover, the fact that DFNA5 is regulated by P53 strongly suggests that DFNA5 is a tumor suppressor gene.

Specifications

Catalog number

EM1901-48

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

2310037D07Rik antibody 4932441K13Rik antibody Deafness, autosomal dominant 5 antibody Deafness, autosomal dominant 5 protein antibody DFNA5 antibody DFNA5 gene antibody DFNA5_HUMAN antibody Dfna5h antibody EG14210 antibody Fin15 antibody ICERE 1 antibody ICERE-1 antibody Inversely correlated with estrogen receptor expression 1 antibody Non-syndromic hearing impairment protein 5 antibody Nonsyndromic hearing impairment protein antibody

Abbreviation

GSDME

Swiss Prot

O60443 Human

Cellular Locus

Cell membrane, cytosol.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within Human DFNA5 aa 34-214 / 496.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

Hela cell lysates, HepG2 cell lysates, SiHa, rat testis tissue, human skin tissue, human breast carcinoma tissue, human placenta tissue, SH-SY5Y.

Concentration

2 mg/mL

Dilution

WB:1:500-1:2,000 ;IF-Cell:1:50-1:100 ;IHC-P:1:50-1:200 ;FC:1:50-1:100

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 55 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No