ERK2 Mouse Monoclonal Antibody [B10-8] — image 1 of 3

Product details

ERK2 Mouse Monoclonal Antibody [B10-8]

Catalog number EM1901-53

Price for EM1901-53

Size / count 100 µL

About this product

Mitogen-activated protein kinase (MAPK) signaling pathways involve two closely related MAP kinases, known as extracellular-signal-related kinase 1 (ERK 1, p44) and 2 (ERK 2, p42). Growth factors, steroid hormones, G protein-coupled receptor ligands, and neurotransmitters can initiate MAPK signaling pathways. Activation of ERK1 and ERK2 requires phosphorylation by upstream kinases such as MAP kinase kinase (MEK), MEK kinase and Raf-1. ERK1 and ERK2 phosphorylation can occur at specific tyrosine and threonine sites mapping within consensus motifs that include the Threonine-Glutamate-Tyrosine motif. ERK activation leads to dimerization with other ERKs and subsequent localization to the nucleus. Active ERK dimers phosphorylate serine and threonine residues on nuclear proteins and influence a host of responses that include proliferation, differentiation, transcription regulation and development. The human ERK2 gene maps to chromosome 22q11.21 and encodes a 360-amino acid protein.

Specifications

Catalog number: EM1901-53
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: ERK 2 antibody ERK-2 antibody ERT1 antibody Extracellular Signal Regulated Kinase 2 antibody Extracellular signal-regulated kinase 2 antibody MAP kinase 1 antibody MAP kinase 2 antibody MAP kinase isoform p42 antibody MAPK 1 antibody MAPK 2 antibody Mapk1 antibody MAPK2 antibody Mitogen-activated protein kinase 1 antibody Mitogen-activated protein kinase 2 antibody MK01_HUMAN antibody P38 antibody P40 antibody P41 antibody p42-MAPK antibody P42MAPK antibody PRKM1 antibody PRKM2 antibody protein kinase, mitogen-activated, 1 antibody protein kinase, mitogen-activated, 2 antibody protein tyrosine kinase ERK2 antibody
Abbreviation: MAPK1
Swiss Prot: P28482 Human, P63085 Mouse
Cellular Locus: Nucleus, spindle, centrosome, cytoplasm, caveola.
Host: Mouse
Species Reactivity: Human, Mouse
Immunogen: Recombinant protein within human ERK2 aa 200-360.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IHC-P, FC
Positive Control: Hela cell lysate, 293T cell lysate, NIH/3T3 cell lysate, K562 cell lysate, human skin tissue, human breast carcinoma tissue, mouse testis tissue, mouse colon tissue, mouse ovary tissue, K562.
Concentration: 2 mg/mL
Dilution: WB:1:500-1:2,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 41 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for ERK2 Mouse Monoclonal Antibody [B10-8]?

The catalog number for ERK2 Mouse Monoclonal Antibody [B10-8] is EM1901-53.

What sizes are available for ERK2 Mouse Monoclonal Antibody [B10-8]?

ERK2 Mouse Monoclonal Antibody [B10-8] is available in the following size(s): 100 µL.

Is ERK2 Mouse Monoclonal Antibody [B10-8] in stock?

ERK2 Mouse Monoclonal Antibody [B10-8] is currently made to order / not held in immediate stock. Contact us for lead time.

What is ERK2 Mouse Monoclonal Antibody [B10-8] used for?

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.