RUVB2 Mouse Monoclonal Antibody [A1E12]

About this product

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes.

Specifications

Catalog number

EM1901-58

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

48 kDa TATA box-binding protein-interacting protein antibody 48 kDa TBP-interacting protein antibody 48-kDa TATA box-binding protein-interacting protein antibody 48-kDa TBP-interacting protein antibody 51 kDa erythrocyte cytosolic protein antibody CGI-46 antibody EC=3.6.1.- antibody ECP-51 antibody ECP51 antibody Erythrocyte cytosolic protein, 51-KD antibody INO80 complex subunit J antibody INO80J antibody MGC144733 antibody MGC144734 antibody MGC52995 antibody mp47 antibody p47 antibody p47 protein antibody Repressing pontin 52 antibody Reptin 52 antibody REPTIN antibody RuvB (E coli homolog)-like 2 antibody RUVB, E. coli, homolog-like 2 antibody RuvB-like 2 (E. coli) antibody RuvB-like 2 antibody RuvB-like protein 2 antibody RUVB2 antibody RUVB2_HUMAN antibody RUVBL2 antibody RVB2 antibody TAP54-beta antibody TATA box-binding protein-interacting protein, 48-KD antibody TBP-interacting protein, 48-KD antibody TIH2 antibody TIP48 antibody TIP49b antibody TIP60-associated protein 54-beta antibody wu:fi25f01 antibody zreptin antibody

Abbreviation

RUVBL2

Swiss Prot

Q9Y230 Human, Q9WTM5 Mouse,

Cellular Locus

Nucleus matrix, nucleoplasm, cytoplasm, membrane.

Host

Mouse

Species Reactivity

Human, Mouse, Rat, Monkey

Immunogen

Recombinant protein within Human RUVB2 aa 130-321 / 463.

Isotype

IgG2b

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

HeLa cell lysate, Daudi cell lysate, HepG2 cell lysate, SK-Br-3 cell lysate, 293T cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, C6 cell lysate, PC-12 cell lysate, COS-1 cell lysate, mouse testis tissue lysate, rat testis tissue lysate, mouse thymus tissue lysate, rat thymus tissue lysate, HeLa, RAW264.7, human trachea tissue, human placenta tissue, human testis tissue, mouse testis tissue, rat testis tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:200-1:1,000

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 51 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No