LYRIC Mouse Monoclonal Antibody [6-F4] — image 1 of 2

Product details

LYRIC Mouse Monoclonal Antibody [6-F4]

Catalog number EM1901-61

Price for EM1901-61

Size / count 100 µL

About this product

Metadherin, also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene. MTDH (AEG-1) is involved in HIF-1alpha mediated angiogenesis. MTDH also interacts with SND1 and involved in RNA-induced silencing complex (RISC) and plays very important role in RISC and miRNA functions. MTDH has been shown to interact with spliceosome proteins in the cell nucleus and regulate the process of alternative splicing. MTDH induces an oncogene called Late SV40 factor (LSF/TFCP2) which is involved in thymidylate synthase (TS) induction and DNA biosynthesis synthesis. Late SV40 factor (LSF/TFCP2) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). MTDH acts as an oncogene in melanoma, malignant glioma, breast cancer and hepatocellular carcinoma. It is highly expressed in these cancers and helps in progression and development of these cancers. It is induced by c-Myc oncogene and plays very important role in anchorage independent growth of cancer cells. Elevated expression of the metastasis gene metadherin (MTDH), which is overexpressed in more than 40% of breast cancers, is associated with poor clinical outcomes.

Specifications

Catalog number: EM1901-61
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: 3D3 antibody 3D3/LYRIC antibody AEG 1 antibody AEG-1 antibody AEG1 antibody Astrocyte elevated gene 1 antibody Astrocyte elevated gene-1 protein antibody LYRIC antibody LYRIC/3D3 antibody LYRIC_HUMAN antibody Lysine rich CEACAM1 associated protein antibody Lysine rich CEACAM1 co isolated protein antibody Lysine-rich CEACAM1 co-isolated protein antibody Metadherin antibody Metastasis adhesion protein antibody MTDH antibody Protein LYRIC antibody
Abbreviation: MTDH
Swiss Prot: Q86UE4 Human
Cellular Locus: Nucleus membrane, nucleolus, endoplasmic reticulum membrane, tight junction, perinuclear region, cytoplasm.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within Human LYRIC aa 6-233 / 582.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, FC
Positive Control: MCF-7 cell lysate, Jurkat cell lysate, Hela cell lysate, K562.
Concentration: 2 mg/mL
Dilution: WB:1:500-1:2,000 ;FC:1:50-1:100
Purity: Protein G affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 64 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for LYRIC Mouse Monoclonal Antibody [6-F4]?

The catalog number for LYRIC Mouse Monoclonal Antibody [6-F4] is EM1901-61.

What sizes are available for LYRIC Mouse Monoclonal Antibody [6-F4]?

LYRIC Mouse Monoclonal Antibody [6-F4] is available in the following size(s): 100 µL.

Is LYRIC Mouse Monoclonal Antibody [6-F4] in stock?

LYRIC Mouse Monoclonal Antibody [6-F4] is currently made to order / not held in immediate stock. Contact us for lead time.

What is LYRIC Mouse Monoclonal Antibody [6-F4] used for?

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.