CD43 Mouse Monoclonal Antibody [A2F8]

About this product

This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4+ T-cells and to a lesser extent by CD8+ T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1.

Specifications

Catalog number

EM1901-70

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

CD 43 antibody CD43 antibody CD43 antigen antibody Galactoglycoprotein antibody GALGP antibody GPL 115 antibody GPL115 antibody Human gene for sialophorin antibody Leucocyte sialoglycoprotein antibody LEUK_HUMAN antibody Leukocyte large sialoglycoprotein antibody Leukocyte sialoglycoprotein antibody Leukosialin antibody LSN antibody Ly-48 antibody sialophorin (gpL115, leukosialin, CD43) antibody Sialophorin antibody Spn antibody

Abbreviation

SPN

Swiss Prot

P16150 Human

Cellular Locus

Membrane, microvillus, uropodium, Nucleus, PML body.

Host

Mouse

Species Reactivity

Human

Immunogen

Synthetic peptide within C-terminal human CD43.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

K562 cell lysates, human B lymphocyte tumor tissue, human tonsil tissue, HL-60.

Concentration

2 mg/mL

Dilution

WB:1:500 ;IHC-P: 1:1,000 ;FC:1:50-1:100

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 40 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No