MTA2 Mouse Monoclonal Antibody [17A2]

About this product

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Specifications

Catalog number

EM1901-74

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

DKFZp686F2281 antibody Mata1l1 antibody Metastasis associated 1 family member 2 antibody Metastasis associated 1 like 1 antibody Metastasis associated gene 1 like 1 antibody Metastasis associated gene family member 2 antibody Metastasis associated protein 2 antibody Metastasis associated protein MTA 2 antibody Metastasis associated protein MTA2 antibody Metastasis-associated 1-like 1 antibody Metastasis-associated protein MTA2 antibody Mmta2 antibody MTA1 L1 protein antibody MTA1-L1 protein antibody MTA1L1 antibody MTA2 antibody MTA2_HUMAN antibody p53 target protein in deacetylase complex antibody PID antibody

Abbreviation

MTA2

Swiss Prot

O94776 Human, Q9R190 Mouse,

Cellular Locus

Nucleus.

Host

Mouse

Species Reactivity

Human, Rat, Mouse

Immunogen

Recombinant protein within Human MTA2 aa 77-286 / 668.

Isotype

IgG2b

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

HeLa cell lysate, K-562 cell lysate, 293T cell lysate, Jurkat cell lysate, Raji cell lysate, MCF7 cell lysate, human breast cancer tissue, human colon cancer tissue, human skin tissue, rat skin tissue, human breast tissue, human esophagus tissue, human pancreas tissue, MCF-7

Concentration

2 mg/mL

Dilution

WB: 1:500-1:3,000 ;IHC-P: 1:500-1:3,000 ;FC: 1:50-1:100

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 75 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No