Cytokeratin 19 Mouse Monoclonal Antibody [A3D5]

About this product

The keratin gene family is a large group of intermediate filament and structural proteins that provide the structural components of hair, nails, horns, scales, claws and similar types of hard tissues. Keratins are also important for intracellular stability in epithelial tissues and different keratins often display organ- or tissue specific expression patterns. Due to these specific expression patterns, keratins are often used as diagnostic biomarkers. Keratin 19 is a type I keratin and expressed in simple epithelia including glandular cell types present in the GI-tract, female tissues, male tissues, and respiratory epithelium. Clinically, keratin 19 is used together with keratin 18 to distinguish hepatocellular cancer from cholangiocellular carcinoma (both keratins are expressed in bile ducts, but keratin 18 is expressed in hepatocytes whereas keratin 19 is not). Keratin 19 is a type I keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically found in the periderm, the transiently superficial layer that envelops the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.

Specifications

Catalog number

EM1901-76

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

40 kDa keratin intermediate filament antibody CK 19 antibody CK-19 antibody CK19 antibody Cytokeratin 19 antibody Cytokeratin-19 antibody K19 antibody K1C19_HUMAN antibody K1CS antibody Keratin 19 antibody Keratin type I 40 kD antibody Keratin type I 40kD antibody Keratin type I cytoskeletal 19 antibody Keratin, type I cytoskeletal 19 antibody Keratin, type I, 40 kd antibody Keratin-19 antibody KRT19 antibody MGC15366 antibody

Abbreviation

Keratin, type I cytoskeletal 19, Cytokeratin-19, CK-19, K19, Keratin-19, KRT19.

Swiss Prot

P08727 Human

Cellular Locus

Cytoskeleton,Cytosol.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within Human Keratin 19 aa 128-322.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

MCF-7 cell lysates, JAR, human pancreas tissue, human colon cancer tissue, human breast tissue, human small intestine tissue, MCF-7.

Concentration

2 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IHC-P: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 44 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No